"Workbook" outline

Just so you have this if you can't get onto Blackboard: the outline I showed in class last Friday. Not really a workbook, but I'll work on that request in future. Contains new stuff about tissues.

Keeping it together (cell mechanics and cell mechanisms)

The Plasma membrane: (pp66-70: text finishes on p69, diagrams on p70).

How does the membrane keep it together?

Side box: how is a cell membrane like a tent canvas?

A. The membrane itself

· Function

o Bag for keeping things in

§ What things?

o Immigration/emigration control

§ List of molecules that go in/out

§ List of types of ‘holes’ in membrane

B. Membrane junctions

·

Side box: getting things in and out of the tent

Function

· Types

o D

o T

o G

Cytoskeleton (pp90-95: text finishes on p95, but ignore table 3.3 on pp94-5)

(Picture of red blood cells)

What holds the cell membrane in shape?

C. Tubules and filaments

· Microtubules

o

Side box: holding the tent up, poles and ropes

Structure

o Function

· Microfilaments

o Structure

o Function

· Intermediate filaments

o Structure

o

Side box: moving round in the tent, flapping the tent walls, swimming tents?

Function

D. Movement

· Moving organelles around in the cell

· Cilia and flagella movements

· Moving the cell membrane

· Examples from cell division

Migrating cells (pp111, 112, 111, 68, 83-84)

How do cells know where they are/should be?

Side box: where is my tent in this campsite/country?

E. Where am I?

· Superficial and deep

· Inside, outside and in-between

· Head-tail, tummy-back, proximal-distal

Side box: taking my tent down & going home, or putting up more tents

Should I be here?

· Apoptosis

· Hyperplasia & wound healing

· Atrophy

F. The extracellular matrix

· Body fluids

·

Side box: what’s the countryside like outside, can I move my tent easily?

Extracellular matrix

o Loose connective tissue

§ Areolar

§ Adipose

§ Reticular

o Dense regular connective tissue

§ Tendons & ligaments

§ Fascia

o Dense irregular connective tissue

§ Cartilage

· Hyaline

· Elastic

· Fibrocartilage

§ Bone

§ (Blood)

G. Proteins in the cellular membrane

· Peripheral proteins

· Intercellular joining (mooring your boat)

· Cell to cell recognition (got your swipe card?)

o glycoproteins

· Attachment to cytoskeleton & the extracellular matrix (tethering your cow!)

H. The glycocalyx (sugar coating)

· CAMs

· Function of CAMs

o ‘Velcro’

o Movement in wound repair

o Indicating wound site

o Tension monitors

o Signalling

· Signals

o Physical (touch)

Chemical

Electrical

o Chemical

o Electrical

Massage Therapy: Connection & relevance to Massage Therapy?